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'Fertile' Root Cell from 'Ordinary' Skin Cell



– In the US, scientists have produced stem cells from skin cells through genomic editing in experiments on mice

In a study conducted at the Gladstone Institute in the US, a single gene in the genomic chain was activated to transform ordinary skin cells into "stimulated multiple fertile" stem cells.

– Scientists in the US produced stem cells from skin cells through genomic editing in experiments on mice

Researchers at the private Gladstone Institute in San Francisco, USA, succeeded in transforming ordinary skin cells into "stimulated multiple fertile" stem cells (iPSCs) by activating a single gene in the genomic chain with genomic editing technology called "CRISPR."

"We discovered a new method of producing stem cells"

At the beginning of the research, the researcher of the Gladstone Institute, who stated that they are moving from the question "Is it possible to reprogram the cell by activating a specific gene in the genomic chain"? Sheng Ding stated that they were discovering a new method of producing stem cells on this count.

From the Gladstone Institute. In 2006, Shinya Yamanaka began producing iPSC from ordinary skin cells for the first time in science history. Yamanaka did this by adding 4 types of protein to ordinary cells. These proteins, called "transcription factors", determine which genes are expressed in the cell. Thus, these proteins suppressed the expression of genes related to skin cells and enabled expression of genes related to stem cells.

Following Yamanaka's pioneering work, Ding and other researchers have developed a different way of transforming ordinary cells into stem cells by adding chemicals other than transcription factors. The new method allows the researcher to generate iPSC by directly modifying the gene's gene expression without any additions.

Cells of the iPSC type can be transformed into all kinds of cells in the body. Therefore, it is very important for the treatment of irreparable tissue damage such as heart attack, parkinson disease and blindness. In addition, stem cells produced in the laboratory environment function as models in disease investigations and new drug tests.

The findings of the research were published in the "Cell Stem Cell" magazine.

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